Urinary tract infection (UTI) remains very common. As many as 50% of w
omen report having had at least one UTI in their lifetimes. Urinary tr
act infection is the most common cause of infection in nursing home re
sidents and the most common source of bacteremia in the elderly popula
tion, Urinary tract infection occurs in patients with structurally or
functionally abnormal urinary tracts (complicated UTI) and in patients
with anatomically normal urinary tracts (uncomplicated UTI), Escheric
hia coli (E coli) is the most common cause of uncomplicated UTI, where
as antibiotic-resistant Enterobacteriaceae, enterococci, and Candida s
pecies often are the causes of complicated UTI. In this article we rev
iew current concepts of the epidemiology, microbiology, pathophysiolog
y, clinical manifestations, diagnosis, and treatment of urinary tract
infection.