TRIMETHOPRIM-SULFADIMIDINE 1 2 MOLECULAR-COMPLEX MONOHYDRATE/

In the title compound, C14H18N4O3.2C(12)H(14)N(4)O(2)S.H2O, trimethopr im [5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine, TMP] interacts w ith one sulfadimidine -N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamid e, SDMD] molecule through two N-H ... N hydrogen bonds forming an eigh t-membered ring, as in the 1:1 methanolate complex, with no proton tra nsfer from the imino sulfonamide N atom to the pyrimidine N atom of th e partner. Association with the second sulfadimidine molecule (SDMD') occurs through an NH N interaction involving the same pyrimidine N ato m of TMP (which therefore acts as a double acceptor) and the NH imino group of the sulfonamide. The water molecule bridges the sulfonamido O atom and the p-aminophenyl group of SDMD' of two molecular complex un its.