PREVENTION OF INTESTINAL CANCER BY RESISTANT STARCH .1. COLORECTAL CARCINOGENESIS - MOLECULAR MECHANISMS, MANIFESTATION OF POLYPOUS AND NON-POLYPOUS CARCINOMA, CHANGES IN COLON-CRYPT STRUCTURE CAUSED BY APCE-GENE DEFECTS

Colorectal carcinoma result from germinal and somatic mutations. In co ntrast to monogenetic DNA defects intestinal carcinogenesis is a long- term complex process. Several decades may elapse between the primary d efect and the directly manifestated development of colorectal carcinom a. Without doubt nutritional factors have a great influence on carcino genesis. The authors show what nutritional factors may contribute to - prevent primary defects initiating carcinogenesis -reduce the colorect al rate of carcinomas in high risk groups, -support other preventive a nd therapeutical measures, and -reduce the risk of further tumor devel opment in the duodenum at the papilla vateri after curative-surgical t herapy.