IMMUNOABLATION DOES NOT DELAY THE NEUROLOGIC PROGRESSION OF X-LINKED ADRENOLEUKODYSTROPHY

Authors
NOWACZYK MJM SAUNDERS EF TEIN I BLASER SI CLARKE JTR
Citation
Mjm. Nowaczyk et al., IMMUNOABLATION DOES NOT DELAY THE NEUROLOGIC PROGRESSION OF X-LINKED ADRENOLEUKODYSTROPHY, The Journal of pediatrics, 131(3), 1997, pp. 453-455
Citations number
13
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
131
Issue
3
Year of publication
1997
Pages
453 - 455
Database
ISI
SICI code
0022-3476(1997)131:3<453:IDNDTN>2.0.ZU;2-G
Abstract
We report the results of a near total myeloablation in preparation for bone marrow transplantation in a boy with minimal symptoms of X-linke d adrenoleukodystrophy. Severe cerebral X-linked adrenoleukodystrophy developed in the patient after failure of bone marrow transplantation. This experience suggests that immunotherapy alone is not responsible for the improvement observed in some patients with X-ALD after BMT.