PRODUCTION OF CYCLOSPORINE-A BY SOLID-STATE FERMENTATION

Authors
SEKAR C RAJASEKAR VW BALARAMAN K
Citation
C. Sekar et al., PRODUCTION OF CYCLOSPORINE-A BY SOLID-STATE FERMENTATION, Bioprocess engineering, 17(4), 1997, pp. 257-259
Citations number
8
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Bioprocess engineering → ACNP
ISSN journal
0178515X
Volume
17
Issue
4
Year of publication
1997
Pages
257 - 259
Database
ISI
SICI code
0178-515X(1997)17:4<257:POCBSF>2.0.ZU;2-Q
Abstract
The production of Cyclosporin A using wheat bran as the solid substrat e was attempted using Tolypocladium sp. and it was found that the yiel d was 10 times more than the yield obtained by submerged fermentation. Hydrolysing the wheat bran using dilute HCl was found to increase the yield. Different solvents were used for the optimization of extractio n of Cyc A from the fermented bran.