HAIRY-CELL LEUKEMIA VARIANT WITH T(2-8)(P12-Q24) ABNORMALITY

Hairy cell leukemia variant is an uncommon chronic B-cell lymphoprolif erative disorder characterized clinically by splenomegaly and marked l eukocytosis. Cytologically, the leukemic cells are distinguishable fro m those of classical hairy cell leukemia by the presence of single, ce ntral, and vesicular nucleoli. Cytogenetic information for this uncomm on leukemia is scanty, although structural abnormalities involving 7q3 4 have been reported in few cases. We report a patient with hairy cell leukemia variant who has t(2;8)(p12;q34) but with c-MYC oncogene rear rangement. (C) Elsevier Science Inc., 1997.