CYTOGENETIC AND FLUORESCENCE IN-SITU HYBRIDIZATION ANALYSES OF A MICROCYSTIC ADNEXAL CARCINOMA WITH DEL(6)(Q23Q25)

Cytogenetic analysis of a case of microcystic adnexal carcinoma (MAC) revealed three unrelated clones with the karyotypes: 46,XX,del(6)(q23q 25)[17]/46,XX,1 similar to 2dmin[4]/46,XX,t(1;3) (p10;q10)[2]. Analysi s of the 6q- by fluorescence in situ hybridization (FISH) showed that it had resulted from a long arm deletion. The finding of a clonal 6q d eletion as the sole karyotypic change in a MAC is of special interest because we previously have identified 6q deletions in different types of malignant salivary gland tumors. This observation, together with th e histopathologic similarities between salivary gland tumors and sweat gland tumors, further emphasize the histogenetic relationships betwee n these tumor types. (C) Elsevier Science Inc., 1997.