CHROMOSOMAL-ABNORMALITIES IN LOW-GRADE CHONDROSARCOMA AND A REVIEW OFTHE LITERATURE

In this study, cytogenetic analysis of two low-grade chondrosarcomas r evealed relatively simple chromosomal complements with structural rear rangements involving chromosomes 1, 6, and 12 [46,XY, add(16)(q24)[3]/ 46,XY,t(1;20)(q21;q11), t(6;17)(q23;q23)[3]/46,XY, t(4;14)(q12;q24), t (5;6)(q12;p21) [2] and 45,XY, t(12;16)(q13;q24), -14[17]/44,idem,add(4 )(p16), -17,[2] respectively]. Previously published reports of chondro sarcoma have revealed structural abnormalities of chromosomes 1, 6, 9, 12, and 15 as common. Also, a correlation between the simplicity or c omplexity of the abnormalities seen and histologic grade has been sugg ested. The findings of the current study support these earlier observa tions. (C) Elsevier Science Inc., 1997.