Fd. Dias et al., EFFECT OF TAXOL ON CHROMOSOME-ABERRATIONS INDUCED BY GAMMA-RADIATION OR BY DOXORUBICIN IN CHINESE-HAMSTER OVARY CELLS, Brazilian journal of genetics, 20(3), 1997, pp. 389-395
Combined therapy with radiation and chemotherapy has being increasingl
y used in cancer treatment. The effect of combinations of taxol (0.08
mu g/ml) with doxorubicin (DXR, 0.5 or 1.0 mu g/ml) or gamma radiation
(20 or 40 cGy) was examined in two different treatment schedules (pre
treatment or simultaneous treatment) using Chinese hamster ovary (CHO)
cells treated at the G2 phase of the cell cycle. The results showed t
hat taxol did not have a radiosensitizing effect on the chromosomal ab
errations induced by gamma radiation nor did it have a potentiating ef
fect on the chromosomal aberrations induced by DXR in CHO cells treate
d in the G2 phase of the cell cycle.