EFFECT OF TAXOL ON CHROMOSOME-ABERRATIONS INDUCED BY GAMMA-RADIATION OR BY DOXORUBICIN IN CHINESE-HAMSTER OVARY CELLS

Combined therapy with radiation and chemotherapy has being increasingl y used in cancer treatment. The effect of combinations of taxol (0.08 mu g/ml) with doxorubicin (DXR, 0.5 or 1.0 mu g/ml) or gamma radiation (20 or 40 cGy) was examined in two different treatment schedules (pre treatment or simultaneous treatment) using Chinese hamster ovary (CHO) cells treated at the G2 phase of the cell cycle. The results showed t hat taxol did not have a radiosensitizing effect on the chromosomal ab errations induced by gamma radiation nor did it have a potentiating ef fect on the chromosomal aberrations induced by DXR in CHO cells treate d in the G2 phase of the cell cycle.