CLASTOGENIC ACTIVITY OF INTEGERRIMINE DETERMINED IN MOUSE MICRONUCLEUS ASSAYS

Authors
GIMMLERLUZ MC ERDTMANN B
Citation
Mc. Gimmlerluz et B. Erdtmann, CLASTOGENIC ACTIVITY OF INTEGERRIMINE DETERMINED IN MOUSE MICRONUCLEUS ASSAYS, Brazilian journal of genetics, 20(3), 1997, pp. 405-409
Citations number
21
Categorie Soggetti
Genetics & Heredity
Journal title
Brazilian journal of genetics
ISSN journal
01008455 → ACNP
Volume
20
Issue
3
Year of publication
1997
Pages
405 - 409
Database
ISI
SICI code
Abstract
The pyrrolizidine alkaloid integerrimine, obtained from Senecio brasil iensis, was tested by acute dosing at two concentrations (18.75 and 37 .5 mg/kg), and at different times, to establish its ability to induce micronuclei in mouse erythrocytes. This alkaloid was able to increase the frequency of micronucleated polychromatic erythrocytes in both, bo ne marrow and peripheral blood erythrocytes.