LOSS OF HETEROZYGOSITY AT CHROMOSOMES 8P, 9P, AND 14Q IS ASSOCIATED WITH STAGE AND GRADE OF NON-PAPILLARY RENAL-CELL CARCINOMAS

In this study, 105 non-papillary renal cell carcinomas (RCCs) have bee n examined for allelic loss at the chromosome 8p12-21,1, 9p21, and 14q 24.2-qter regions, each by two highly polymorphic microsatellites. Los s of heterozygosity (LOH) was detected at both chromosome 8p and 9p in 33 per cent of the cases and at chromosome 14q in 45 per cent of the tumours, A correlation of variables such as size, grade, and stage of tumours with these specific genetic alterations showed that loss of ch romosomes 8p and 9p, and especially loss of chromosome 14q regions, is significantly associated with a higher grade of tumour and the combin ed LOH at these chromosomal sites with advanced tumour stage. These ge netic alterations did not show any correlation with the size of non-pa pillary RCCs, This study suggests that genetic markers at the above-me ntioned chromosomal sites can predict the clinical outcome of non-papi llary RCCs, (C) 1997 John Wiley & Sons, Ltd.