NONCIRRHOTIC HEPATOMA PRESENTING WITH PARANEOPLASTIC NEUROLOGIC MANIFESTATIONS - 2 CASES

Hepatocellular carcinoma usually occurs in patients with cirrhosis and is rarely associated with paraneoplastic neurologic disorders, We des cribe two young patients with hepatomas occurring in noncirrhotic live rs, bath of whom presented with neurologic symptoms, A 19-yr-old man w ho presented with coma and a 23-yr-old woman with a 3-month history of progressive hemiparesis, dysarthria, and altered affect were each fou nd, at autopsy, to have hepatocellular carcinoma occurring in a noncir rhotic liver, Neuropathologic examinations revealed widespread multifo cal necrotizing leukoencephalopathy in the man and occlusive noninflam matory cerebral vasculopathy with widespread cortical and subcortical infarcts in the woman, It is unlikely that the neuropathologic finding s in these patients are explicable on the basis of antibody-mediated t issue injury.