Bacteria, such as Escherichia coli and Azospirillum brasilense, avoid
microenvironments with elevated oxygen concentrations, not by sensing
reactive oxygen derivatives, but by sensing a metabolic down-shift tha
t results from elevated oxygen levels. A novel protein, Aer, and the c
hemotaxis serine receptor, Tsr, have recently been identified as trans
ducers for aerotaxis which monitor internal energy levels in the bacte
ria.