ALPHAVIRUSES AS EXPRESSION VECTORS

Authors
Citation
K. Lundstrom, ALPHAVIRUSES AS EXPRESSION VECTORS, Current opinion in biotechnology, 8(5), 1997, pp. 578-582
Citations number
46
Categorie Soggetti
Biothechnology & Applied Migrobiology","Biochemical Research Methods
ISSN journal
09581669
Volume
8
Issue
5
Year of publication
1997
Pages
578 - 582
Database
ISI
SICI code
0958-1669(1997)8:5<578:AAEV>2.0.ZU;2-2
Abstract
Alphavirus vectors have been used for efficient high-level expression of a variety or topologically different proteins, allowing studies oi protein transport, localization and functional activity in a broad ran ge of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology. Al phavirus vectors have also shown promising potential in vaccine produc tion and preliminary gene therapy applications.