PROTEIN-KINASE INHIBITION BY STAUROSPORINE REVEALED IN DETAILS OF THEMOLECULAR INTERACTION WITH CDK2

Authors
LAWRIE AM NOBLE MEM TUNNAH P BROWN NR JOHNSON LN ENDICOTT JA
Citation
Am. Lawrie et al., PROTEIN-KINASE INHIBITION BY STAUROSPORINE REVEALED IN DETAILS OF THEMOLECULAR INTERACTION WITH CDK2, Nature structural biology, 4(10), 1997, pp. 796-801
Citations number
41
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
10
Year of publication
1997
Pages
796 - 801
Database
ISI
SICI code
1072-8368(1997)4:10<796:PIBSRI>2.0.ZU;2-Z
Abstract
Staurosporine exhibits nanomolar IC50 values against a wide range of p rotein kinases. The structure of a CDK2 strauroporine complex explains the tight binding of this inhibitor and suggests features to be explo ited in the design of specific inhibitors of CDKs.