INTERRATER VARIABILITY IN REPORTING ENHANCING LESIONS PRESENT ON STANDARD AND TRIPLE DOSE GADOLINIUM SCANS OF PATIENTS WITH MULTIPLE-SCLEROSIS

In this study we evaluated and compared the inter-rater variabilities in detecting enhancing lesions in patients with MS after injection of a standard dose (s.d) and a triple dose (TD) of gadolinium (Gd). Enhan ced magnetic resonance imaging (MRI) were obtained in 15 patients, con sisting of T-1-weighted images 5 to 7 min after the injection of the s dd (0.1 mmol/kg) of Gd end, after on interval of 6 to 24 h, 5 to 7 min after the injection of the TD (0.3 mmol/kg). An additional scan 1 h a fter the TD injection (delayed scanning -DS) was obtained in 11 patien ts. The scans were independently evaluated in a random order by four o bservers. Lesions were counted and scored according to size and locati on. The level of interobserver concordance was very high for reporting the total numbers of enhancing lesions, their sizes and sites for the three experimental conditions. No significant differences were found in inter-observer variability in reporting the total number of enhanci ng lesions and their location in different brain sites in the three co nditions. Our data indicate that the gain in sensitivity in detecting enhancing lesions in MS with the TD is not counteracted by a loss in r eproducibility. This is important in planning clinical trials in which the number of enhancing lesions is used as a measure of outcome.