Purpose: We determined the efficacy of atropine sulfate combined with
papaverine hydrochloride, prostaglandin El and phentolamine mesylate i
n the pharmacological erection test. Materials and Methods: A total of
230 consecutive patients with erectile dysfunction was randomized for
pharmacological erection test and received an intracorporeal combinat
ion of 50 mg. papaverine hydrochloride, 10 mu g. prostaglandin El, 0.2
mg. phentolamine mesylate and 0.075 mg, of atropine sulfate (group I)
, or the same combination without atropine sulfate (group 2). Erectile
response was evaluated subjectively and by intracorporeal pressure me
asurement. Results: In group 1, 40 patients (35.1%) showed only tumesc
ence, and 22 (19.3%) had poor erection, In group 2, 45 patients (39.5%
) had tumescence and 17 (14.9%) poor erection. In both groups 52 patie
nts (45.6%) had rigid erection. There was no statistically significant
difference regarding erectile response and intracorporeal pressure. C
onclusions: The addition of atropine sulfate did not improve results o
f the pharmacological erection test when combined with 50 mg, papverin
e hydrochloride, 10 mu g., prostaglandin El, and 0.2 mg. phentolamine
mesylate.