ALTERATIONS IN GENE-EXPRESSION ASSOCIATED WITH PRIMARY DEMYELINATION AND REMYELINATION IN THE PERIPHERAL NERVOUS-SYSTEM

Citation
Ad. Toews et al., ALTERATIONS IN GENE-EXPRESSION ASSOCIATED WITH PRIMARY DEMYELINATION AND REMYELINATION IN THE PERIPHERAL NERVOUS-SYSTEM, Neurochemical research, 22(10), 1997, pp. 1271-1280
Citations number
91
Categorie Soggetti
Biology,Neurosciences
Journal title
ISSN journal
03643190
Volume
22
Issue
10
Year of publication
1997
Pages
1271 - 1280
Database
ISI
SICI code
0364-3190(1997)22:10<1271:AIGAWP>2.0.ZU;2-L
Abstract
Primary demyelination is an important component of a number of human d iseases and toxic neuropathies. Animal models of primary demyelination are useful for isolating processes involved in myelin breakdown and r emyelination because the complicating events associated with axonal de generation and regeneration are not present. The tellurium neuropathy model has proven especially useful in this respect. Tellurium specific ally blocks synthesis of cholesterol, a major component of PNS myelin. The resulting cholesterol deficit in myelin-producing Schwann cells r apidly leads to synchronous primary demyelination of the sciatic nerve , which is followed by rapid synchronous remyelination when tellurium exposure is discontinued. Known alterations in gene expression for mye lin proteins and for other proteins involved in the sequence of events associated with demyelination and subsequent remyelination in the PNS are reviewed, and new data regarding gene expression changes during t ellurium neuropathy are presented and discussed.