Atherosclerosis and inflammatory arterial diseases are rare in young p
eople. Since the early 1980s, an increasing incidence of iliac arteria
l stenosis in competition cyclists has been reported. Histological fin
dings in these individuals are specific, with fibrosis of the intimal
wall on histology and no atherosclerotic or inflammatory lesions. Clin
ical consequences of this arterial endofibrosis are usually described
as an exercise-related subjective sensation of swollen thigh in one or
both (15%) legs, with normal clinical and Doppler investigations at r
est. Following maximal exercise, ankle-to-brachial systolic pressure i
ndex is lower than 0.5 in 85% of individuals with disease and is used
as a key argument for diagnosis before deciding upon arteriography. Su
rgery (recalibrated saphenous grafts or angioplasty-endofibrosectomy)
seems to be efficient to allow an early return to competition, but its
long term results are still to be evaluated. The physiopathology of t
his disease and its possible relationship with atherosclerosis are unk
nown.