CONTRIBUTION TO THE DETERMINATION OF THE CHEMOTHERAPEUTIC DRUG G1 IN BIOLOGICAL-FLUIDS

Authors
DELVALLE LG MICHAEL DGW RODRIGUEZ AM PERAZA RT RAMOS F AVILA JP
Citation
Lg. Delvalle et al., CONTRIBUTION TO THE DETERMINATION OF THE CHEMOTHERAPEUTIC DRUG G1 IN BIOLOGICAL-FLUIDS, Journal of chromatography B. Biomedical sciences and applications, 698(1-2), 1997, pp. 312-316
Citations number
9
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical sciences and applications → ACNP
ISSN journal
13872273
Volume
698
Issue
1-2
Year of publication
1997
Pages
312 - 316
Database
ISI
SICI code
0378-4347(1997)698:1-2<312:CTTDOT>2.0.ZU;2-V
Abstract
A sensitive gas chromatographic method for the quantitative determinat ion of the new antibacterial and antifungal drug G1, 1-(5-bromofuran-2 -yl)-2-bromo-2-nitroethene, has been optimized. The method involves a fast and single extraction step from spiked serum and urine samples. T he G1 drug was quantified using an internal standard method and by mea ns of a nitrogen-selective detector. The results are statistically sig nificant and show that mean levels of G1 as low as 1 mu g ml(-1) can b e measured accurately. (C) 1997 Elsevier Science B.V.