HYDRODYNAMIC AND RHEOLOGICAL PARAMETERS OF BLOOD IN PATIENTS SUBJECTED TO CARDIAC-SURGERY - EFFECT OF POLYETHYLENE OXIDE

Rheological and hydrodynamic properties of blood taken from patients w ith atherosclerosis and rheumatic disease before, immediately after, a nd in 16 hours after cardiac surgery were compared with data obtained in a control group which comprised practically healthy persons, Prior to operation signs of hyperviscosity syndrome were revealed, Cardiac s urgery with cardiopulmonary bypass was associated with marked hemodilu tion (hematocrit decrease by 41-52%) and shift of rheological paramete rs (blood viscosity, red cells aggregation, fibrinogen) to control val ues, In 16 hours after surgery red cells aggregation and fibrinogen co ntent tended to return to preoperative level, In postoperative period sustained disturbances of hydrodynamic properties of the blood (a fall in turbulent flow rate) occurred, Addition of 3-10(-6) g/ml poly(ethy lene)oxide to blood samples led to restoration of hydrodynamic propert ies of the blood and maintenance of red cells aggregation on a level c lose to control values.