SIDE-EFFECTS OF ANTICONVULSANTS IN TREATMENT OF IDIOPATHIC GENERALIZED EPILEPSY

This investigation was ainced on detection of frequency and main featu res of side effects of anticonvulsants in therapy of idiopathic genera lized epilepsy. There were observed 190 patients aged 5-29 yeras suffe ring from different forms of idiopathic generalized epilepsy. Side eff ects were revealed in 48,4% of patients as a result of the investigati on. Almost half of patients (49,0%) who were administred valproic acid developed dde effects. Neuroendocrine disfunctions and digestive dist urbances were the most frequent. Side effects were revealed within the first two monthes after administration of valproats. Only in 13,2% of cases the treatment and to be stopped at the expence of severeness of side effects. Barbiturates caused side effects in 39,6%, of cases. To xic damage of CNS was the nest significant, Hyperkinetic syndrome with lack of attention was observed 37,9% of cases, Succinimides caused si de effects in 37,9% of cases,Toxic damage of CNS was the most frequent -in 22,4% of cases, digestive disturbances was in 15,5% of cases. Ther e are no really effective means for correction of above mentioned side effects.