INVESTIGATION OF MYASTHENIA IN TWINS

Twin pairs with one or two myasthenic patients were selected from pati ents with neuromuscular pathology. 18 couples of twins were included i n final selection (9 monozygotic and 9 dizygotic pairs). 4 pairs of mo nozygotic twins were concordant To myasthenia (MA). All dizygotic pair s were discordant to this disease. matched concordantness of monozygot ic twins was 44%. Penetration of pathological gene was 64% assuming th e hypothesis about monogenic heredity of MA, The coefficient of heredi ty was 44%, The conclusion was made about important, but not absolute role of hereditary factors in development of MA, It was necessary the presence of combination of both genetic and environmental factors for MA development.