Y. Shounan et al., MYELOPROLIFERATIVE DISEASE AND MYELODYSPLASTIC SYNDROME INDUCED BY TRANSPLANTATION OF BONE-MARROW CELLS EXPRESSING MUTANT P53, Leukemia, 11(10), 1997, pp. 1641-1649
p53 mutations are the most common genetic alterations observed in huma
n cancers including lymphomas and leukemias. We have previously shown
that transduction of normal murine hematopoietic cells with mutant p53
alone in vitro results in an enhanced proliferative capacity and modi
fied differentiation potential of transduced cells. In order to invest
igate further the role of mutant p53 in hematopoietic cell transformat
ion, mutant p53-transduced bone marrow cells were used to reconstitute
the hematopoietic system of lethally irradiated mice. The results sho
w that overexpression of mutant p53 can initiate the transformation of
immature murine hematopoietic cells in vivo and induce two types of h
ematopoietic disorders, myeloproliferative disease and myelodysplastic
syndrome.