BERYLLIUM-INDUCED BIOCHEMICAL-ALTERATIONS AND THEIR PREVENTION FOLLOWING COADMINISTRATION OF MESO-2,3-DIMERCAPTOSUCCINIC ACID OR 2,3-DIMERCAPTOPROPANE SULFONATE IN RATS
S. Mathur et al., BERYLLIUM-INDUCED BIOCHEMICAL-ALTERATIONS AND THEIR PREVENTION FOLLOWING COADMINISTRATION OF MESO-2,3-DIMERCAPTOSUCCINIC ACID OR 2,3-DIMERCAPTOPROPANE SULFONATE IN RATS, Journal of applied toxicology, 14(4), 1994, pp. 263-267
The effects of meso-2,3 dimercaptosuccinic acid (DMSA) and 2,3 dimerca
ptopropane sulphonate (DMPS) on body beryllium burden, hepatic lipid p
eroxidation, glutathione, alkaline and acid phosphatase and some bioch
emical variables of porphyrin metabolism were studied in beryllium-poi
soned rats. It was observed that beryllium poisoning is associated wit
h a slight increase in lipid peroxidation, significant depletion of al
kaline phosphatase and elevation of acid phosphatase activities in the
liver and increased beryllium concentration in blood and other soft o
rgans. Evidence is presented that both DMSA and DMPS during concomitan
t administration prevented most of the above beryllium-induced biochem
ical alterations. Tissue beryllium concentration and histopathological
lesions in liver and kidneys were also significantly less marked foll
owing simultaneous administration of DMPS compared to beryllium-expose
d controls; DMSA was comparatively less effective.