H. Pfeiffer et al., ORIGIN OF HEPATOCELLULAR-CARCINOMA RECURRING AFTER ALLOTRANSPLANTATION REVEALED BY MICROSATELLITE ANALYSIS, Journal of Clinical Pathology, 50(9), 1997, pp. 792-794
A hepatocellular carcinoma was resected from a liver allotransplant af
ter the patient's original organ had been removed because of a liver c
arcinoma, DNA analysis was performed to explore the origin of the carc
inoma cells. Dla?A extracted from the carcinoma tissue, from the carci
noma free liver tissue, and from other cells of the recipient underwen
t polymerase chain reaction amplification for seven microsatellite sys
tems and the X-Y amelogenin system. The allelic pattern from the carci
noma tissue was identical with that from the patient and differed from
the DNA profile of the liver tissue. The result confirmed the assumpt
ion that the carcinoma tissue had originated from the patient and not
from the donor.