Objectives: To describe the changes over time of the QRS interval and
terminal 40-msec QRS frontal axis (T40-ms) in patients with acute tric
yclic antidepressant poisoning, to identify clinical factors and treat
ment associated with these changes, and to determine if patients with
tricyclic antidepressant-related complications (seizures and/or arrhyt
hmias) had differences in such serial electrocardiogram (EGG) changes
when compared with patients without complications. Design: Prospective
, observational, cohort study. Setting: Emergency departments of commu
nity and university-based hospitals in Massachusetts that consulted a
large regional poison center. Patients: Thirty-six patients who presen
ted with an acute ingestion (<24 hrs) of a tricyclic antidepressant, w
ho had at least three electrocardiograms in the first 8 hrs and serial
ECGs until discharge, and who had a peak tricyclic antidepressant con
centration of >300 ng/mL. Interventions: None. Measurements and Main R
esults: The maximal limb-lead QRS interval and T40-ms axis were measur
ed manually in all ECGs, The maximum recorded QRS interval occurred at
the time of presentation for 24 (80%) of 30 patients whose QRS was gr
eater than or equal to 100 msecs and a median time of 3 hrs (range 1 t
o 9) for the other six patients, The maximum recorded T40-ms axis occu
rred at the time of presentation for 31 (86%) of 36 patients and at a
median time of 3 hrs (range 1 to 5) for the remaining five patients, T
he minimum QRS interval observed remained greater than or equal to 100
msecs in 15 patients (range 100 to 140 msecs) and decreased to (100 m
secs in 15 patients, The median time from presentation to the first EC
G with a QRS<100 msecs was 20 hrs (range 1 to 153) in those 15 patient
s, There were no significant differences in clinical characteristics a
nd treatment (including sodium bicarbonate therapy) between the two gr
oups, The minimum recorded T40-ms remained greater than or equal to 12
0 degrees in 30 patients and decreased to <120 degrees in six patients
, The median time from presentation until the first ECG with a T40-ms
axis <120 degrees was 13 hrs (range 2 to 30) for the six patients, All
ECG measurements were greater and remained abnormal for a significant
ly longer duration in those patients who developed seizures and/or ven
tricular arrhythmias. These two ECG parameters demonstrated ongoing ch
anges and persistent abnormalities despite clinical improvement in all
patients except one. Conclusions: The conduction abnormalities seen i
n severe tricyclic antidepressant toxicity vary widely in the time obs
erved for resolution of these abnormalities and sometimes remain persi
stently abnormal, Ail ECG parameters were significantly more abnormal
in those patients who developed seizures and/or arrhythmias, Clinical
improvement occurred both before and during these ECG changes.