PREDICTION OF THE LIPOPHILICITY OF SOME PLANT GROWTH-STIMULATING AMIDO ESTERS OF ETHANOLAMINE USING REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY

Using reversed-phase high-performance thin-layer chromatography with o ctadecylsilane-bonded silica gel as the stationary phase and methanol- water as the mobile phase, several new compounds (amido esters of etha nolamine) were studied. The R(m) values were plotted versus methanol m olar fraction (x) and a linear correlation was obtained, R(m) = a(o) a(1)X, characterized by high values of the correlation coefficient, r . The R(m) values for X = 0 (organic solvent content), (R(m))(x=o) = a (o), can be used to elucidate the lipophilicity of the studied compoun ds. The log P values were calculated using fragmental constants. A goo d correlation was found between a(o) and log P, with r = 0.929.