THE SYNTHESIS OF 8,8-DISUBSTITUTED TRICYCLIC ANALOGS OF ARTEMISININ

Authors
HARALDSON CA KARLE JM FREEMAN SG DUVADIE RK AVERY MA
Citation
Ca. Haraldson et al., THE SYNTHESIS OF 8,8-DISUBSTITUTED TRICYCLIC ANALOGS OF ARTEMISININ, Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2357-2362
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
18
Year of publication
1997
Pages
2357 - 2362
Database
ISI
SICI code
0960-894X(1997)7:18<2357:TSO8TA>2.0.ZU;2-F
Abstract
Two tricyclic analogs of artemisinin were designed based on a Comparat ive Molecular Field Analysis (CoMFA) model, and synthesized for antima larial testing as part of a program to construct and validate modeling tools for drug design of novel antimalarial agents based on the natur al product lead, (+)-artemisinin. (C) 1997 Elsevier Science Ltd.