SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,3,4-TETRAHYDROQUINOLINE AND 3,4-(1H)-DIHYDROQUINOLIN-2-ONE ANALOGS OF RETINOIC ACID

Authors
BEARD RL TENG M COLON DF DUONG TT THACHER SM AREFIEG T CHANDRARATNA RAS
Citation
Rl. Beard et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,3,4-TETRAHYDROQUINOLINE AND 3,4-(1H)-DIHYDROQUINOLIN-2-ONE ANALOGS OF RETINOIC ACID, Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2373-2378
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
18
Year of publication
1997
Pages
2373 - 2378
Database
ISI
SICI code
0960-894X(1997)7:18<2373:SABO1A>2.0.ZU;2-O
Abstract
Retinoids are natural and synthetic analogs of the hormone retinoic ac id. Retinoids are currently being investigated clinically as drugs in several areas, including dermatology and oncology. We report the synth esis and biological activity of a new series of potent, RAR-specific r etinoids substituted with a 1,2,3,4-tetrahydroquinoline or a 3,4-(1H)- dihydroquinolin-2-one group. (C) 1997 Elsevier Science Ltd.