IMIDAZOLE AND TRIAZOLE SUBSTITUTED ETHER PHOSPHOLIPIDS - POTENT ANTITUMOR AGENTS

Authors
NAIR HK PETERSON AC YAZDI PT FRANZMAIR R
Citation
Hk. Nair et al., IMIDAZOLE AND TRIAZOLE SUBSTITUTED ETHER PHOSPHOLIPIDS - POTENT ANTITUMOR AGENTS, Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2379-2382
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
18
Year of publication
1997
Pages
2379 - 2382
Database
ISI
SICI code
0960-894X(1997)7:18<2379:IATSEP>2.0.ZU;2-E
Abstract
Two novel ether phospholipids containing an imidazole and a triazole a t the C-2 position of the glyceryl chain, respectively, were synthesiz ed and evaluated as antitumor agents. Both compounds inhibited the gro wth of a number of tumor cell lines in vitro; IC50 values ranged from 1 to 6 mu M for MCF-7, MDA-MB-231, HT-29 and HL-60 tumor cell lines. ( C) 1997 Elsevier Science Ltd.