A NEW SERIES OF SELECTIVE DOPAMINE-D4 LIGANDS - ARYLPIPERAZIN-1-YL]ALKYLAMINO)-2H-1,4-BENZOXAZINES

Authors
HE XS WOODRUFF K BRODBECK R
Citation
Xs. He et al., A NEW SERIES OF SELECTIVE DOPAMINE-D4 LIGANDS - ARYLPIPERAZIN-1-YL]ALKYLAMINO)-2H-1,4-BENZOXAZINES, Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2399-2402
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
18
Year of publication
1997
Pages
2399 - 2402
Database
ISI
SICI code
0960-894X(1997)7:18<2399:ANSOSD>2.0.ZU;2-C
Abstract
A series of 4-arylpiperaz-1-yl)alkylamino]-2H-1,4-benzoxazines were pr epared and their affinities for cloned human D-2, D-3, and D-4 dopamin e receptor subtypes were measured. This led to the identification of 1 a, 1f, and 1g as high affinity selective antagonists at the D-4 recept or. (C) 1997 Elsevier Science Ltd.