IS GLUCOSE-TOLERANCE FACTOR AN ARTIFACT PRODUCED BY ACID-HYDROLYSIS OF LOW-MOLECULAR-WEIGHT CHROMIUM-BINDING SUBSTANCE

Authors
SUMRALL KH VINCENT JB
Citation
Kh. Sumrall et Jb. Vincent, IS GLUCOSE-TOLERANCE FACTOR AN ARTIFACT PRODUCED BY ACID-HYDROLYSIS OF LOW-MOLECULAR-WEIGHT CHROMIUM-BINDING SUBSTANCE, Polyhedron, 16(23), 1997, pp. 4171-4177
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear",Crystallography
Journal title
Polyhedron → ACNP
ISSN journal
02775387
Volume
16
Issue
23
Year of publication
1997
Pages
4171 - 4177
Database
ISI
SICI code
0277-5387(1997)16:23<4171:IGFAAP>2.0.ZU;2-4
Abstract
A low-molecular-weight chromium-binding substance (LMWCr) has been iso lated and purified from porcine kidney and porcine kidney powder and c haracterized. The oligopeptide is biologically active, has a molecular weight of ca 1500 daltons, and is comprised of cysteine, glycine, glu tamate, aspartate, and Cr-III. Porcine kidney LMWCr is also susceptibl e to hydrolysis, especially under the conditions for the acid hydrolys is used in the purification of glucose tolerance factor (GTF). Combine d with some similarities in the composition of GTF and LMWCr, these re sults suggest GTF may be an artifact resulting from hydrolysis of porc ine LMWCr. (C) 1997 Elsevier Science Ltd.