3 CASES OF BONE-MARROW NECROSIS IN ACUTE-LEUKEMIA

Bone marrow necrosis (BMN) is mostly diagnosed at postmortem examinati on. It has been observed in association with acute leukemia and other malignant diseases. We report here BMN in two patients with acute myel oid leukemia (AML) and one with acute lymphocytic leukemia (ALL) in wh om the diagnosis was made while alive. Two patients died because of in tracraneal bleeding. One with AML(M5) developed BMN one week after he was treated with a second course of chemotherapy: he had a complete re covery and remains in remission almost five years after the diagnosis. We conclude that antemortem diagnosis of BMN is technically difficult , but as it is not always associated to a fatal prognosis, an early di agnosis and vigorous supportive therapy should be attempted.