Objective: To characterize HIV seroprevalence and risk behavior among
injecting drug users (IDUs) in Rio de Janeiro, Brazil, between 1990 an
d 1996. Design: We report data from three separate cross-sectional sam
ples of IDUs in Rio de janeiro: the World Health Organization (WHO) sa
mple (n = 479), the Proviva sample (n = 138) and the Brasil sample (n
= 110). These data provide the most comprehensive view available, to d
ate, of this understudied population in Rio. Methods: Demographic char
acteristics, HIV/AIDS risk behavior and HIV seroprevalence were compar
ed across the three samples and combined analyses were performed to de
termine the factors associated with injecting risk behavior, sexual ri
sk behavior and HIV seropositivity. Results: The overall HIV seropreva
lence among IDUs was 25%. Two encouraging findings of the present anal
ysis were the lower levels of needle-sharing among participants recrui
ted in the latest years (1995-1996) and the lower HIV seroprevalence i
n the Proviva sample composed mainly of less educated, poorer IDUs liv
ing in deprived neighborhoods. No trends toward safer behavior were fo
und for sexual risk, younger age being the principal factor associated
with high risk. Conclusions: Levels of needle-sharing and sexual risk
among IDUs in Rio remain high, demonstrating the urgent need to incre
ase the limited preventive measures undertaken so far. Seroprevalence
levels for HIV remain significantly lower in the most deprived sample,
arguing for the fundamental importance of prompt and effective preven
tion strategies to keep infection rates from rising among the poorest
and largest strata of Rio's IDUs.