CD10 - A REVIEW

The antigen defined by the cluster designation group 10 (CD 10) has al so been called common acute lymphoblastic leukemia antigen (CALLA) and neutral endopeptidase (NEP). This antigen is expressed by a variety o f normal cell types, including lymphoid precursor cells, germinal cent er B lymphocytes, and some epithelial cells. On the cell surface, CD10 is an enzyme that functions to reduce the cellular response to peptid e hormones. On neoplastic cells, the antigen is detected in a high per centage of cases of acute lymphoblastic leukemia (ALL), follicular lym phoma, Burkitt's lymphoma, and some nonhematopoietic tumors. CD10 is n ot a lineage-specific antigen, but its detection may be of value in co mbination with other antibodies. The detection of this antigen is most valuable in the diagnosis and classification of lymphoblastic maligna ncies, follicular lymphomas, and Burkitt's lymphoma.