BREAST-CANCER - THE HIGH-RISK MUTATIONS

Mutations in the two known BRCA genes account for only 5% to 10% of br east cancer, The genes may play a role in genomic stability; their rol e in sporadic cancer remains unknown, Hence, genetic testing has creat ed clinical dilemmas, Some pertain to women whose family history sugge sts inherited risk. Others, including the false reassurance that may b e conferred by a negative finding, apply throughout the general popula tion.