The occurrence of a congenital neurological disorder ''spinal dysmyeli
nation'' in cross-bred calves in Denmark is reported. A total of 36 af
fected calves of the Red Danish Dairy breed X American Brown Swiss wer
e detected. The calves occurred in a clear familiar pattern consistent
with an autosomal recessively inherited trait, and the parents could
be traced to a common ancestor. Clinically the disease was characteriz
ed by congenital lateral recumbency, opisthotonos, extension of the li
mbs, normal to increased reflexes, and normal alertness. At histologic
al examination dysmyelination occurred constantly in specific spinal t
racts.