Skin lesions were studied in a 3-year-old male Maltese dog with distem
per. Hyperkeratosis and parakeratosis with vesicles and pustule format
ion were the outstanding features of the skin lesions around the eye,
nose, and mouth. Multinucleated syncytial giant cells together with nu
clear and cytoplasmic inclusion bodies containing viral particles and
viral antigen were scattered in the epidermis, and epidermal appendage
s. These findings suggest a direct viral attack on the skin.