NICKEL-CATALYZED ADDITION OF ORGANOZINCATES TO OPTICALLY PURE VINYLICSULFOXIDES - SYNTHESIS OF THE PHOSPHODIESTERASE-IV INHIBITOR L-765,527 (CDP-840)

Authors
HOUPIS IN MOLINA A DORZIOTIS I REAMER RA VOLANTE RP REIDER PJ
Citation
In. Houpis et al., NICKEL-CATALYZED ADDITION OF ORGANOZINCATES TO OPTICALLY PURE VINYLICSULFOXIDES - SYNTHESIS OF THE PHOSPHODIESTERASE-IV INHIBITOR L-765,527 (CDP-840), Tetrahedron letters, 38(41), 1997, pp. 7131-7134
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
41
Year of publication
1997
Pages
7131 - 7134
Database
ISI
SICI code
0040-4039(1997)38:41<7131:NAOOTO>2.0.ZU;2-Z
Abstract
Ph3ZnMgCl was added to the optically pure sulfoxide 3 in the presence of Ni(acac)(2) to give, after desulfurization, the phosphodiesterase I V inhibitor 1 in good yield and 92% enantiomeric excess. (C) 1997 Else vier Science Ltd.