HIGH-YIELD PROTECTION OF PURINE RIBONUCLEOSIDES FOR H-PHOSPHONATE RNA-SYNTHESIS

Authors
ZHANG XH ABAD JL HUANG QT ZENG F GAFFNEY BL JONES RA
Citation
Xh. Zhang et al., HIGH-YIELD PROTECTION OF PURINE RIBONUCLEOSIDES FOR H-PHOSPHONATE RNA-SYNTHESIS, Tetrahedron letters, 38(41), 1997, pp. 7135-7138
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
41
Year of publication
1997
Pages
7135 - 7138
Database
ISI
SICI code
0040-4039(1997)38:41<7135:HPOPRF>2.0.ZU;2-I
Abstract
We report a new method for protecting nucleosides for hydrogen phospho nate RNA synthesis that gives very high yields for the purines. This m ethod is based on our finding that, for adenosine and guanosine, silyl ation of a mixture of 2' and 3' H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl. (C) 1997 Elsevier Science Ltd .