A CHEMOSELECTIVE RHODIUM(II) MEDIATED SOLID-PHASE 1,3-DIPOLAR CYCLOADDITION AND ITS APPLICATION TO A THERMALLY SELF-CLEAVING FURAN SCAFFOLD

Authors
WHITEHOUSE DL NELSON KH SAVINOV SN AUSTIN DJ
Citation
Dl. Whitehouse et al., A CHEMOSELECTIVE RHODIUM(II) MEDIATED SOLID-PHASE 1,3-DIPOLAR CYCLOADDITION AND ITS APPLICATION TO A THERMALLY SELF-CLEAVING FURAN SCAFFOLD, Tetrahedron letters, 38(41), 1997, pp. 7139-7142
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
41
Year of publication
1997
Pages
7139 - 7142
Database
ISI
SICI code
0040-4039(1997)38:41<7139:ACRMS1>2.0.ZU;2-X
Abstract
A chemoselective rhodium(II) mediated 1,3-dipolar cycloaddition reacti on on solid-phase for the construction of a template-directed scaffold is described. In this paper, the reaction of acetylenes with isomunch nones is presented as a general methodology for the combinatorial form ation of a furan based library. Additionally, through the development of a novel thermolytic cleavage step, this furan synthesis yields pure product from the solid-phase in a temperature dependent manner. (C) 1 997 Elsevier Science Ltd.