AMEBA - AN ACID-SENSITIVE ALDEHYDE RESIN FOR SOLID-PHASE SYNTHESIS

Authors
FIVUSH AM WILLSON TM
Citation
Am. Fivush et Tm. Willson, AMEBA - AN ACID-SENSITIVE ALDEHYDE RESIN FOR SOLID-PHASE SYNTHESIS, Tetrahedron letters, 38(41), 1997, pp. 7151-7154
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
41
Year of publication
1997
Pages
7151 - 7154
Database
ISI
SICI code
0040-4039(1997)38:41<7151:A-AAAR>2.0.ZU;2-U
Abstract
Oxidation of 4-(3-methoxy-4-hydroxymethylphenoxy)methyl polystyrene re sin produced AMEBA resin 1, a novel acid sensitive aldehyde resin. Red uctive amination of AMEBA resin generated resin bound amines which wer e derivatized as sulfonamides, amides, ureas, and carbamates. Cleavage of the resin under mild acidic conditions generated the derivatized a mines in high purity and moderate yield. (C) 1997 Elsevier Science Ltd .