A NOVEL LINKAGE FOR THE SOLID-PHASE SYNTHESIS OF HYDROXAMIC ACIDS

Authors
BAUER U HO WB KOSKINEN AMP
Citation
U. Bauer et al., A NOVEL LINKAGE FOR THE SOLID-PHASE SYNTHESIS OF HYDROXAMIC ACIDS, Tetrahedron letters, 38(41), 1997, pp. 7233-7236
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
41
Year of publication
1997
Pages
7233 - 7236
Database
ISI
SICI code
0040-4039(1997)38:41<7233:ANLFTS>2.0.ZU;2-O
Abstract
A novel linkage for the solid-phase synthesis of hydroxamic acids is d escribed and its facile application for the solid phase synthesis of p eptidyl, succinyl and urea-type hydroxamic acids is illustrated. Cleav age is induced under mild acidic conditions by treatment with formic a cid in THF, providing hydroxamic acids in high purity and fair to good yields. (C) 1997 Elsevier Science Ltd.