A MILD AND EFFICIENT METHOD FOR SELECTIVE CLEAVAGE OF KETALS AND ACETALS USING LITHIUM-CHLORIDE IN WATER-DIMETHYL SULFOXIDE

Authors
MANDAL PK DUTTA P ROY SC
Citation
Pk. Mandal et al., A MILD AND EFFICIENT METHOD FOR SELECTIVE CLEAVAGE OF KETALS AND ACETALS USING LITHIUM-CHLORIDE IN WATER-DIMETHYL SULFOXIDE, Tetrahedron letters, 38(41), 1997, pp. 7271-7274
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
41
Year of publication
1997
Pages
7271 - 7274
Database
ISI
SICI code
0040-4039(1997)38:41<7271:AMAEMF>2.0.ZU;2-3
Abstract
A mild and efficient neutral aqueous method for selective cleavage of acetals and ketals to the corresponding carbonyl compounds has been es tablished by using LiCl in H2O-DMSO at elevated temperature. While ary l and alpha,beta-unsaturated ketals and acetals underwent smooth cleav age, diaryl, non-aryl and isolated ketals and acetals remained unaffec ted under the reaction conditions. (C) 1997 Elsevier Science Ltd.