IDIOPATHIC TORSION DYSTONIA LINKED TO CHROMOSOME-8 IN 2 MENNONITE FAMILIES

Authors
ALMASY L BRESSMAN SB RAYMOND D KRAMER PL GREENE PE HEIMAN GA FORD B YOUNT J DELEON D CHOUINARD S SAUNDERSPULLMAN R BRIN MF KAPOOR RP JONES AC SHEN H FAHN S RISCH NJ NYGAARD TG
Citation
L. Almasy et al., IDIOPATHIC TORSION DYSTONIA LINKED TO CHROMOSOME-8 IN 2 MENNONITE FAMILIES, Annals of neurology, 42(4), 1997, pp. 670-673
Citations number
27
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
42
Issue
4
Year of publication
1997
Pages
670 - 673
Database
ISI
SICI code
0364-5134(1997)42:4<670:ITDLTC>2.0.ZU;2-U
Abstract
The DYT1 locus on chromosome 9q34 is responsible for most childhood li mb-onset idiopathic torsion dystonia (ITD). Linkage to DYT1 has been e xcluded in families with adult-onset, and predominantly cranial-cervic al, ITD. We mapped a locus (DYT6) associated with prominent cranial-ce rvical ITD in two large Mennonite families to chromosome 8. An identic al haplotype spanning 40-cM segregates with ITD in these families, sug gesting a shared mutation from the recent past.