ASSOCIATION ANALYSIS OF THE 5-HT2C RECEPTOR AND 5-HT TRANSPORTER GENES IN BIPOLAR DISORDER

We selected 42 patients with bipolar disorder type I (BPI) and 40 heal thy controls for genetic analysis of DNA polymorphisms in the serotoni n receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes, No si gnificant associations were found in the total patient sample, However , when the individuals were divided according to gender, trends for as sociation with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest th at variations in these genes may be responsible for a minor increase i n susceptibility for bipolar disorder in women, (C) 1997 Wiley-Liss, I nc.