Anaplastic large cell lymphoma (ALCL) is a recently described malignan
cy that can show heterogeneity in its clinical presentation, We report
on a patient whose clinical presentation, medical history, and serolo
gic test results were suggestive of tertiary syphilis, Histologic eval
uation, however, revealed a large cell lymphoma with Ki-l positive fin
dings on immunostaining, We review the differential diagnosis of ALCL
and add to that a pattern of ALCL clinically mimicking noduloulcerativ
e tertiary syphilis.