INDUCTION OF HIV-1 SPECIFIC MUCOSAL IMMUNE-RESPONSES BY DNA VACCINATION

Authors
ASAKURA Y HINKULA J LEANDERSSON AC FUKUSHIMA J OKUDA K WAHREN B
Citation
Y. Asakura et al., INDUCTION OF HIV-1 SPECIFIC MUCOSAL IMMUNE-RESPONSES BY DNA VACCINATION, Scandinavian journal of immunology, 46(4), 1997, pp. 326-330
Citations number
32
Categorie Soggetti
Immunology
Journal title
Scandinavian journal of immunology → ACNP
ISSN journal
03009475
Volume
46
Issue
4
Year of publication
1997
Pages
326 - 330
Database
ISI
SICI code
0300-9475(1997)46:4<326:IOHSMI>2.0.ZU;2-7
Abstract
DNA vaccination has been shown to induce immunity against several diff erent pathogens including HIV-1. The authors demonstrate here that adm inistration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, t he intranasal route provides a further means of application for DNA im munization.