BIOSYNTHESIS OF DIKETOPIPERAZINE ALKALOIDS BY THE FUNGUS PENICILLIUM-FELLUTANUM BOIURGE VKM F-3020

The growth of the fungus Penicillium fellutanum VKM F-3020 in a submer ged culture on Abe medium was accompanied by synthesis of diketopipira zine alkaloids (fellutanines A-E). Exogenous tryptophan was utilized i n the processes of primary metabolism but did not affect the alkaloid biosynthesis. The maximum alkaloid accumulation and yield per unit bio mass were observed in glutamate-containing medium. The fungal culture synthesized fellutanines A-E irrespective of the cultivation medium us ed. The nitrogen source affected the ratio between the synthesized alk aloids but not their qualitative pattern. However, when phenylalanine was used as the only nitrogen source, tryptophylphenylalanyl diketopip erazine (isorugulosuvine) was synthesized in addition to fellutanines A-E.